Protein Details: Neuronal acetylcholine receptor subunit alpha-5

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate; although this is independent of metabolic activity (By similarity). .

Sequence

PDB Structures

Ligand Binding